N-Acetic acid-indole-3-carboxaldehyde
N-Acetic acid-indole-3-carboxaldehyde
CAS: 138423-98-0
Molecular Formula: C11H9NO3
N-Acetic acid-indole-3-carboxaldehyde - Names and Identifiers
N-Acetic acid-indole-3-carboxaldehyde - Physico-chemical Properties
| Molecular Formula | C11H9NO3 |
| Molar Mass | 203.19 |
| Density | 1.30±0.1 g/cm3(Predicted) |
| Melting Point | 197-200°C(lit.) |
| Boling Point | 458.5±25.0 °C(Predicted) |
| Flash Point | 231.1°C |
| Vapor Presure | 3.34E-09mmHg at 25°C |
| Appearance | Solid |
| BRN | 5431204 |
| pKa | 4.15±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Sensitive | Air Sensitive |
| Refractive Index | 1.621 |
| MDL | MFCD00452923 |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ WGK Germany:3 |
N-Acetic acid-indole-3-carboxaldehyde - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
N-Acetic acid-indole-3-carboxaldehyde - Introduction
Indole formaldehyde resin was synthesized by coupling to ammonia resin. Amines and derivatives can be fixed by the reductive amination reaction of the polyaldehyde resin. Mild cleavage with 50% TFA 1
Last Update：2022-10-16 17:13:45
N-Acetic acid-indole-3-carboxaldehyde - Reference Information
| Uses | N-acetic acid -3-indole formaldehyde is an organic intermediate. |
| Preparation | N-acetic acid -3-indole formaldehyde can be prepared by the nucleophilic substitution reaction of 3-formyl indole and ethyl bromoacetate (3-formyl indole -1-yl) ethyl acetate, and then hydrolyze the ester group to prepare N-acetic acid -3-indole formaldehyde. 3-formyl indole (10g,69mmol) was dissolved in N,N-dimethylformamide (100mL), and the temperature was kept below 15 ℃ under external cooling under nitriding atmosphere. Sodium hydride (60%,3.0g,76mmol in mineral oil) was added in batches. Then, after 30 minutes, ethyl bromoacetate (8.4mL,76mmol) of N,N-dimethylformamide (15mL) solution was added dropwise, and the resulting mixture was stirred at room temperature for 16 hours. Concentrate the mixture in vacuum so that the residue is divided between water (300mL) and ethyl acetate (2 × 150mL). The organic extract was combined, washed with saturated ammonium chloride aqueous solution (100mL), dried (MgSO4), and concentrated in vacuum to obtain 15.9g (quantitative) (3-formylindole-1-yl) ethyl acetate, an oil. 1H-NMR(CDCl3):δH = 1.30(3H,t),4.23(2H,q),4.90(2H,s),7.3(3H,m),7.77(1H,s),8.32(1H,d),10.0(1H,s). will (3-formyl indole -1-yl) ethyl acetate (15.9g,69mmol) is dissolved in 1,4-dioxane (100mL), 1N sodium hydroxide (10mL) is added, and the obtained mixture is stirred at room temperature for 4 days. Water (500mL) was added and the mixture was washed with diethyl ether (150mL). The aqueous phase was acidified with 5N hydrochloric acid and extracted with ethyl acetate (250 150mL). The organic extract was combined, dried (MgSO4) and concentrated in vacuum to obtain 10.3g(73%) N-acetic acid -3-indole formaldehyde as solid. 1H-NMR(DMSO-d6):δH=5.20(2H,s),7.3(2H,m),7.55(1H,d),8.12(1H,d),8.30(1H,s),9.95(1H,s),13.3(1H,bs). |
Last Update：2024-04-09 21:21:28
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CAS: 138423-98-0
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CAS: 138423-98-0
Tel: 17505222756
Email: pules.cn@gmail.com
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Wechat: 17505222756
Spot supply
Product Name: (3-Formyl-1-indolyl)acetic acid Visit Supplier Webpage Request for quotationCAS: 138423-98-0
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